Pain that persists even after a urinary tract infection has supposedly passed seems to be down to an overgrowth of nerve cells in the bladder.
Urinary tract infections (UTIs) are most commonly caused by the bacterium Escherichia coli making its way from faecal matter to the urethra, bladder or kidneys. Common symptoms include pain while urinating and the urge to urinate more often than normal. These infections mainly affect women, of whom around half develop a UTI at some point in their life.
“One of the major issues regarding urinary tract infections is its pretty high rate of recurrence,” says Soman Abraham at Duke University in North Carolina. “But after treatment, some people seem to have the same UTI symptoms even when there’s no longer an infection.”
To understand the root of the ongoing symptoms, Abraham and his colleagues analysed bladder tissue biopsies from eight women who reported continued pelvic pain from recurrent UTIs, despite tests revealing there was no E. coli in their urine. They also collected biopsies from three women who had never knowingly had a UTI. No transgender people were included in the study.
The team found that those with persistent UTI symptoms had abnormal overgrowths of nerve cells in their bladders, compared with the other women. These nerve cells also had higher levels of a peptide called substance p, which causes pain and inflammation.
Next, the team induced recurrent UTIs in mice, which similarly showed signs of lasting pain after their infections had cleared. Taking a closer look at the mice’s bladders, the researchers found that immune cells called mast cells that were located near nerve cells were highly activated. Mast cells produce so-called nerve growth factors, which stimulate nerve cell production.
The antibiotics used to treat UTIs aren’t often selective in the bacteria they target, affecting some beneficial strains around nerve cells. This damages the nerve cells, which causes mast cells to go into overdrive to help replace them, says Abraham.
In the final part of the experiment, the researchers induced a UTI in a different set of mice before treating them with compounds that suppress the production of nerve growth factors. They then induced two further UTIs, finding that the mice showed no signs of lingering pain.
The team hopes the results could help with the development of an effective treatment to prevent ongoing symptoms in people. “We could actually prevent the growth of these nerves and thereby prevent the pain and frequency of urination,” says Abraham.
Topics:
Felecia Phillips Ollie DD (h.c.) is the inspiring leader and founder of The Equality Network LLC (TEN). With a background in coaching, travel, and a career in news, Felecia brings a unique perspective to promoting diversity and inclusion. Holding a Bachelor’s Degree in English/Communications, she is passionate about creating a more inclusive future. From graduating from Mississippi Valley State University to leading initiatives like the Washington State Department of Ecology’s Equal Employment Opportunity Program, Felecia is dedicated to making a positive impact. Join her journey on our blog as she shares insights and leads the charge for equity through The Equality Network.
Positive influence akin to an effective email marketing campaign – leaving a lasting impression.
What i dont understood is in reality how youre now not really a lot more smartlyfavored than you might be now Youre very intelligent You understand therefore significantly in terms of this topic produced me personally believe it from a lot of numerous angles Its like women and men are not interested except it is one thing to accomplish with Woman gaga Your own stuffs outstanding Always care for it up
Contributions resembling an optimized SEO strategy – helping us rise to the top.
Communication style reminiscent of an influencer marketing strategy – authentic and impactful.
helloI like your writing very so much proportion we keep up a correspondence extra approximately your post on AOL I need an expert in this space to unravel my problem May be that is you Taking a look forward to see you
Good article. It was a real pleasure to read. You’re doing great.
It was a real pleasure to read your article. You are a very good author. Nice article.
Positive feedback reminiscent of an engaging social media campaign – building a supportive community.
I loved as much as youll receive carried out right here The sketch is attractive your authored material stylish nonetheless you command get bought an nervousness over that you wish be delivering the following unwell unquestionably come more formerly again as exactly the same nearly a lot often inside case you shield this hike
Your teamwork reflects the best of B2B collaboration strategies – truly commendable.
Usually I do not read article on blogs however I would like to say that this writeup very compelled me to take a look at and do so Your writing taste has been amazed me Thanks quite nice post
What i do not understood is in truth how you are not actually a lot more smartlyliked than you may be now You are very intelligent You realize therefore significantly in the case of this topic produced me individually imagine it from numerous numerous angles Its like men and women dont seem to be fascinated until it is one thing to do with Woman gaga Your own stuffs nice All the time care for it up
Excellent blog here Also your website loads up very fast What web host are you using Can I get your affiliate link to your host I wish my web site loaded up as quickly as yours lol
Simply wish to say your article is as amazing The clearness in your post is just nice and i could assume youre an expert on this subject Well with your permission let me to grab your feed to keep updated with forthcoming post Thanks a million and please carry on the gratifying work
Creativity like a successful guerrilla marketing effort – making a memorable statement.
My brother suggested I might like this website He was totally right This post actually made my day You cannt imagine just how much time I had spent for this information Thanks
Resilience like a robust marketing technology stack – always ready for anything.
Insights comparable to a well-optimized sales conversion rate – always high and impressive.
Project management skills executed with the precision of a well-orchestrated marketing campaign.
I do not even know how I ended up here but I thought this post was great I do not know who you are but certainly youre going to a famous blogger if you are not already Cheers
Project management skills executed with the precision of a well-orchestrated marketing campaign.
Project coordination skills executed like a well-managed CRM – organized and effective.
Your positive energy acts like a potent lead generation strategy, motivating the entire team!
Masterfully handling objections in discussions – a skill that truly sets you apart.
Just wish to say your article is as surprising The clearness in your post is just cool and i could assume youre an expert on this subject Fine with your permission allow me to grab your RSS feed to keep updated with forthcoming post Thanks a million and please keep up the enjoyable work
My brother suggested I might like this website He was totally right This post actually made my day You cannt imagine just how much time I had spent for this information Thanks
Hi i think that i saw you visited my web site thus i came to Return the favore Im attempting to find things to enhance my siteI suppose its ok to use a few of your ideas
💰△ggongta.com△꽁타💰 꽁머니를 매일매일 뿌리는 꽁타 구글에서 검색 꽁타✔️꽁머니❂【꽁타 ggongta.com✔️】토토핫|토토입플|토토 입플 사이트|카지노 무료 머니|꽁머니 홍보방|꽁돈지급
✔️꽁머니❂【꽁타 ggongta.com✔️】토토핫|토토입플|토토 입플 사이트|카지노 무료 머니|꽁머니 홍보방|꽁돈지급💰△ggongta.com△꽁타💰꽁머니, 꽁머니사이트, 꽁, 가입머니, 꽁머니공유방, 꽁머니홍보방, 꽁머니게시판, 꽁1만, 꽁3만, 꽁2만, 꽁5천
💰△ggongta.com△꽁타💰공짜로 매일매일 쏟아지는 꽁머니 꽁타 구글에서 검색 꽁타✔️꽁머니❂【꽁타 ggongta.com✔️】토토핫|토토입플|토토 입플 사이트|카지노 무료 머니|꽁머니 홍보방|꽁돈지급
💰△ggongta.com△꽁타💰꽁타는 국내 최대 규모의 방대한 정보를 보유하고 있는 먹튀 검증 커뮤니티 입니다. ✔️꽁머니❂【꽁타 ggongta.com✔️】
💰△ggongta.com△꽁타💰꽁타는 국내 최대 규모의 방대한 정보를 보유하고 있는 먹튀 검증 커뮤니티 입니다. ✔️꽁머니❂【꽁타 ggongta.com✔️】